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What is Trigeminal Neuralgia?

The official description of Trigeminal Neuralgia (TN) is:  “sudden, severe, brief, stabbing pain occurring in attacks lasting at the most a few seconds usually only on one side of the face and provoked by light touch”. It is considered to be “the worst pain known to man” and attacks are often described by patients as being like ‘an electric shock’, which may be severe enough to rivet them to the spot or bring them to their knees. The pain can also be described as stabbing, shooting, burning, excruciating, and unlike any other pain previously experienced.  The pain attacks may last for a few seconds or occur in “volleys” — multiple bursts of pain in quick succession — lasting several minutes.  The pain, often triggered by just a light touch to an area of skin, can strike at any time and without warning. Frequency of attacks can vary from a few times a month to several times each day depending on the severity of the condition.  Unfortunately, for most sufferers, the condition is progressive and will worsen over time.  Although to date there is no guaranteed cure for the condition, there are a number of treatments which can give relief.

Where is the pain felt?

The pain is most commonly felt on one side of the face (unilateral) and usually in the cheek or lower jaw. Pain There may also be pain inside the mouth and often it can feel as if it is coming from one or more teeth, hence many people seek the help of their dentist initially and some may undergo unnecessary dental treatment before getting a  correct diagnosis.  In other instances, pain can be felt on the entire side of the face or, occasionally, just around the eye and forehead.  TN tends to affect the right side of the face more than the left side.  Very rarely, it can occur on both sides (this is known as bilateral) but it is rare to have acute pain on both sides at the same time.


What are the causes of Trigeminal Neuralgia?

Although there is still much debate among neuroscientists regarding the causes of TN, it is now generally agreed that the trigeminal nerve is ‘misfiring’ and is sending out inappropriate pain signals.  The trigeminal nerve can be thought of as being like an electric wire or cable that contains numerous fibres conveying different messages to the brain.  There are pain, touch, temperature and vibration fibres, each insulated from one another by a protective sheath called myelin.  The myelin sheath can be damaged by pressure from blood vessels (veins or arteries), multiple sclerosis (MS), injury to the nerve or simply as part of the ageing process.  In a small number of cases, the cause may be due to a tumour or a benign growth pressing on the nerve.

When the nerve is injured it becomes ‘hyper-excited’.  The result is that the nerve fibres inside the nerve itself fire off signals of pain at the least provocation.  Pain fibres can “short circuit” with touch fibres, due to loss of insulating myelin, and this results in a “sparking” between the two, sending incorrect pain signals to the brain.  The myelin tries to heal itself and this sometimes results in successive periods of remission when no pain occurs.

More About the Trigeminal Nerve


There are 12 pairs of nerves called the cranial nerves which provide the nerve supply to the right and left sides of the head and neck.  The trigeminal nerve is the fifth and largest of these and is known medically as ‘V’ since V is the Roman numeral for five.  Its job is to provide nerve sensation from the mouth, face and the front of the scalp, as well as controlling the muscles which are used in chewing (mastication). The trigeminal nerve allows us to experience touch, temperature and pain in the face.  It does not affect the way the face looks; that is a different cranial nerve.

There are numerous small nerve fibres in the face which pick up sensations and transmit them to the brain.  These fibres progressively gather together into three main branches on either side of the
face. These are referred to as V1, V2, and V3:

  • The ophthalmic branch (V1) which runs through the eye, forehead and nose
  • The maxillary branch (V2) which runs through the upper teeth, gums, lips, cheek, lower eyelid and side of the nose
  • The mandibular branch (V3) which runs through the lower teeth, gums and lip

TN Nerve

These three branches then enter the brain through a hole inside the skull and join up to form what is known as the Gasserian ganglion.  The whole nerve then continues to the back of the skull to enter the brain.


Page last updated on 19 Feb 2012